Shingles (Herpes zoster)
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Description:
-Shingles present as a painful unilateral skin lesion that follows a particular nerve on one side of our body (dermatome).
-Shingles is a reactivation of the chickenpox virus that has been dormant in a dorsal root ganglia of a nerve in our body.
-Shingles occurrence increases with age.
-Postherpetic neuralgia (pain affecting the nerves) increases with age:
4% in people 30 to 50 years of age
50% in people over 80 years of age
-Postherpetic neuralgia is defined as a pain persisting at least one month after the rash as healed.
Signs and Symptoms:
Prodromal phase:
-Consisting of tingling, itching, burning sensation, knifelike pain over the involved dermatome prior to the appearance of the rash.
Acute phase:
-Could present with fatigue, headache, low grade fever
-Rash on a dermatomal presentation.
-Redness on one side of the body, followed by grouped vesicules who become pustular or hemorrhagic after 3 to 4 days.
-The rash resolves with the appearance of crusts
-Thoracic and lumbar dermatomes are most commonly affected

Herpes zoster (shingles)
-However any dermatome can be affected and also could presents itself as a disseminated zoster
Chronic phase:
-Postherpetic neuralgia can present in 15% of patients overall and this increases with age
-A small percentage may affect a motor nerve and can cause weakness
Risk factors:
-The vast majority of people don’t have any underlying illness
-Increases with age
-Immuno-compromised patients (HIV, cancer patients, patients with organ transplants on medications)
-History of chickenpox
Treatment:
Time is of essence. The sooner the treatment is started after the appearance of the characteristic rash the more it could be resolved without any complications and the postherpetic neuralgia.
-Antivirals should be started within 48 to 72 hours after the appearance of the rash for maximum benefits. They can prevent the postherpetic neuralgia.
Usually your doctor will use Valtrex® or Famvir® for 7 days of treatment.
-Local treatment with wet dressings of tap water with Burow’s applied 30 to 60 minutes, 4 to 6 times a day.
Calamine could also be used.
Lidoderm® patches can be applied only after skin rash as resolved over the painful area.
-Analgesics such as Tylenol® and anti-inflammatory medication can help but sometimes we will need to use opioids such as Morphine® to relieve the pain.
-Tricyclic antidepressants at low dose such as Elavil® could be started to treat postherpetic neuralgia.
-Neurontin® can also help for postherpetic neuralgia.
-Consultation with an anaesthesiologist or a Pain Clinic for peridural injections can help relieve the pain.
-Evolution of the disease is usually self-limited
Complications:
-Shingles can be transmitted to susceptible persons such as immuno-compromised patients and children who never had Chickenpox.
-Postherpetic neuralgia
-Ocular involvement with facial zoster
-Facial zoster can also cause the Ramsay Hunt syndrome: facial palsy, loss of taste, lesions in the ear canal
-Skin infection over the lesions
-Guillain-Barré syndrome
-Encephalatis
-Transverse myelitis
Prevention:
-Varicella zoster immunoglobulin is recommended for immunocompromised patients who have no history of chickenpox or shingles and who were exposed to someone with chickenpox or shingles.
-Chickenpox vaccine (varicella vaccine) may be administered to patients who never got chickenpox or the shingles.
Disclaimer: Please see your doctor to determine if these treatments are right for you. Don`t auto diagnose or treat yourself before asking your doctor.
Drfeelgood
